Multi-Mycotoxin SPE-Column CossTOX

16 mycotoxins in one go

The CrossTOX ®  columns from LCTech enable highly efficient sample purification of regulated and expected mycotoxins.
At the same time, they improve the conventional dilute-and-shoot application using a QuEChERS-based process.

Original size

All in one

The following 16 mycotoxins have already been successfully tested with the CrossTOX ®  columns:

  • Aflatoxins B1, B2, G1, G2
  • Ochratoxin A
  • Zearalenon
  • Deoxynivalenol
  • Fumonisins B1, B2
  • T-2
  • HT-2
  • Nivalenol
  • 3-acetyl-DON
  • 15-acetyl-DON
  • DON-3Glc
  • Sterigmatocystin

* Regulated mycotoxins are highlighted

Field of application and mode of operation

A specially tailored sorbent guarantees high depletion even with difficult matrices. With CrossTOX ® , grain-based matrices as well as nuts or dried fruit can be processed with great success ( overview of the matrices tested ). The loading capacity is 3 mL (corresponds to 0.6 g matrix).

The cleaning via CrossTOX ® is done either manually or automatically with a robotic system FREESTYLE SPE or, if desired, fully automated in combination with an HPLC direct injection module.

After extraction, centrifugation (optional) and application of the extract to the column, the purified sample can be measured with an LC-MS / MS system. Depending on the matrix, the majority of the analytes are measured without internal standards and with excellent recoveries. By reducing the internal standards and the purity of the sample, enormous costs per sample and maintenance costs (LC-MS / MS) are saved.

Quality is important to us!

All materials are extensively checked for their suitability and quality throughout the entire production process. LCTech meets the high level of European and international legal regulations in mycotoxin analysis. An extensive quality certificate is enclosed with every pack.


Exemplary chromatograms are shown below, which illustrate the matrix depletion and thus represent the purity of the sample through the CrossTOX ® columns:

Pink: rice with dilute-and-shoot (syringe filtration) Black: rice with CrossTOX® columns

Pink: Wheat with dilute and shoot (syringe filtration) Black: Wheat with CrossTOX® columns

Your benefits at a glance

  • High purity of the extracts due to LCTech’s own sorbent for high matrix depletion; no separate filtration
  • Significantly less internal standard required due to special affinity mechanisms of the columns
  • Extension of the cleaning and maintenance intervals of your LC-MS / MS system due to the high purity of the extracts
  • Only one column for all matrices
  • Suitable for manual (syringe) and automated processing (FREESTYLE)